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Mikael Elfman

Researcher

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The new cell irradiation facility at the Lund nuclear probe

Author

  • Natalia Arteaga
  • Jan Pallon
  • Magnus Gram
  • Vaida Auzelyte
  • Mikael Elfman
  • Per Kristiansson
  • Klas Malmqvist
  • Christer Nilsson
  • Marie WegdĂ©n

Summary, in English

The CELLION project is directed towards the studies on cellular response to targeted single ions. This paper gives an account of the modifications made at the Lund sub-micron beam line in order to create a Single Ion Hit Facility for biological applications within the CELLION project. The most relevant new feature is the specially developed software used to locate the cells. A program for cell recognition and localization that gives the coordinates of the centre of the cells has been designed. The recognition is made online. A picture taken by a microscope is used as input parameter for the recognition program. Using V79 Chinese hamster cells, the recognition procedure can be done in less than 0.5 s for a picture size of 800 x 600 pixels with approximately 96% efficiency. This paper also reports target accuracy test results and the first non-targeted irradiation procedure performed at the Lund sub-micron beam line. (c) 2007 Elsevier B.V. All rights reserved.

Department/s

  • Nuclear physics
  • Infection Medicine (BMC)

Publishing year

2007

Language

English

Pages

91-96

Publication/Series

Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

Volume

260

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Infectious Medicine

Keywords

  • irradiation
  • single ions
  • cell
  • CELLION

Conference name

10th International Conference on Nuclear Microprobe Technology and Applications and 2nd International Workshop on Proton Beam Writing

Conference date

2006-07-09 - 2006-07-14

Conference place

Singapore

Status

Published

Research group

  • Nuclear Microprobe

ISBN/ISSN/Other

  • ISSN: 0168-583X