Peter Ekström
Senior lecturer
Method Matters : Exploring Alkoxysulfonate-Functionalized Poly(3,4-ethylenedioxythiophene) and Its Unintentional Self-Aggregating Copolymer toward Injectable Bioelectronics
Author
Summary, in English
Injectable bioelectronics could become an alternative or a complement to traditional drug treatments. To this end, a new self-doped p-type conducting PEDOT-S copolymer (A5) was synthesized. This copolymer formed highly water-dispersed nanoparticles and aggregated into a mixed ion-electron conducting hydrogel when injected into a tissue model. First, we synthetically repeated most of the published methods for PEDOT-S at the lab scale. Surprisingly, analysis using high-resolution matrix-assisted laser desorption ionization-mass spectroscopy showed that almost all the methods generated PEDOT-S derivatives with the same polymer lengths (i.e., oligomers, seven to eight monomers in average); thus, the polymer length cannot account for the differences in the conductivities reported earlier. The main difference, however, was that some methods generated an unintentional copolymer P(EDOT-S/EDOT-OH) that is more prone to aggregate and display higher conductivities in general than the PEDOT-S homopolymer. Based on this, we synthesized the PEDOT-S derivative A5, that displayed the highest film conductivity (33 S cm-1) among all PEDOT-S derivatives synthesized. Injecting A5 nanoparticles into the agarose gel cast with a physiological buffer generated a stable and highly conductive hydrogel (1-5 S cm-1), where no conductive structures were seen in agarose with the other PEDOT-S derivatives. Furthermore, the ion-treated A5 hydrogel remained stable and maintained initial conductivities for 7 months (the longest period tested) in pure water, and A5 mixed with Fe3O4 nanoparticles generated a magnetoconductive relay device in water. Thus, we have successfully synthesized a water-processable, syringe-injectable, and self-doped PEDOT-S polymer capable of forming a conductive hydrogel in tissue mimics, thereby paving a way for future applications within in vivo electronics.
Department/s
- Chemical Biology and Therapeutics
- Clinical Chemistry, Malmö
- Clinical Protein Science and Imaging
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- National Resource Centre for Physics Education
- Nuclear physics
- NanoLund: Centre for Nanoscience
Publishing year
2022
Language
English
Pages
2752-2763
Publication/Series
Chemistry of Materials
Volume
34
Issue
6
Document type
Journal article
Publisher
The American Chemical Society (ACS)
Topic
- Materials Chemistry
- Polymer Chemistry
Status
Published
Research group
- Chemical Biology and Therapeutics
- Clinical Chemistry, Malmö
- Clinical Protein Science and Imaging
ISBN/ISSN/Other
- ISSN: 0897-4756